Preparation and characterization of mangiferin-loaded lipid nanocapsules

Barakat, Sara Sherif; Nasr, Maha Sayed; Mortada, Nahed Daoud; Badawy, Sabry

doi:10.21608/aps.2023.194792.1109

Preparation and characterization of mangiferin-loaded lipid nanocapsules

Document Type : Original Article

Authors

¹ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Misr International University, Cairo, Egypt.

² Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

³ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University

⁴ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Misr International University

10.21608/aps.2023.194792.1109

Abstract

Mangiferin (Mgf), a xanthone glucoside of natural origin, is well known to possess different pharmacological actions such as analgesic, antiviral, antidiabetic, anti-inflammatory, hepatoprotective and antitumor. However, concerning water solubility it is sparingly soluble; in addition it is classified as BCS class IV compound which limits its bioavailability. lipid nanocapsules (LNCs) is a promising carrier for oral delivery as it provides better solubility of the drug and enhances the drug absorption after oral administration owing to its small size. In this study mangiferin-loaded lipid nanocapsules (Mgf-LNCs) were prepared using phase inversion temperature using solutol and cremophor RH40. This was followed by characterization of the formed Mgf-LNCs by measuring particle size (PS), polydispersity index (PDI), zeta potential (ZP), viscosity, in vitro release and the stability after storage was also evaluated. The obtained results showed that PS for the prepared LNCs ranged from 22.88 ± 3.10 to 436.35 ± 69.37 nm. The ZP range of prepared LNCs was from -6.48 ± 2.13 to -1.90 ± 0.08 mV and showed a PDI ranging from 0.05 ± 0.01 to 0.72 ± 0.28 and viscosity ranging from 6.21 ± 2.90 to 1361.20 ± 92.21 mPa*s . The cumulative % release ranged from 48.89 ± 2.54 to 94.33 ± 9.63% after 6 hours period. After storage for 3 months in refrigerator it is clear that the prepared formulae showed significant stability. Finally it is concluded that LNCs is promising nanocarriers for the oral delivery of Mgf.

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