• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Archives of Pharmaceutical Sciences Ain Shams University
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 6 (2022)
Volume Volume 5 (2021)
Issue Issue 2
Issue Issue 1
Volume Volume 4 (2020)
Volume Volume 3 (2019)
Volume Volume 2 (2018)
Volume Volume 1 (2017)
Ungo-kore, H., Olorunmola, E., Ademola, O., Stephen, O. (2021). Assessment of Antidermatophytic Activity and chemical composition of Nigerian Citrus senensis (L.) Osbeck Essential Oil against Multidrug-Resistant Pathogenic dermatophytes Isolated from Tinea capitis Samples. Archives of Pharmaceutical Sciences Ain Shams University, 5(2), 275-287. doi: 10.21608/aps.2021.87917.1066
Hussain Y. Ungo-kore; Ehinmidu J. Olorunmola; Onaolapo J. Ademola; Olonitola O. Stephen. "Assessment of Antidermatophytic Activity and chemical composition of Nigerian Citrus senensis (L.) Osbeck Essential Oil against Multidrug-Resistant Pathogenic dermatophytes Isolated from Tinea capitis Samples". Archives of Pharmaceutical Sciences Ain Shams University, 5, 2, 2021, 275-287. doi: 10.21608/aps.2021.87917.1066
Ungo-kore, H., Olorunmola, E., Ademola, O., Stephen, O. (2021). 'Assessment of Antidermatophytic Activity and chemical composition of Nigerian Citrus senensis (L.) Osbeck Essential Oil against Multidrug-Resistant Pathogenic dermatophytes Isolated from Tinea capitis Samples', Archives of Pharmaceutical Sciences Ain Shams University, 5(2), pp. 275-287. doi: 10.21608/aps.2021.87917.1066
Ungo-kore, H., Olorunmola, E., Ademola, O., Stephen, O. Assessment of Antidermatophytic Activity and chemical composition of Nigerian Citrus senensis (L.) Osbeck Essential Oil against Multidrug-Resistant Pathogenic dermatophytes Isolated from Tinea capitis Samples. Archives of Pharmaceutical Sciences Ain Shams University, 2021; 5(2): 275-287. doi: 10.21608/aps.2021.87917.1066

Assessment of Antidermatophytic Activity and chemical composition of Nigerian Citrus senensis (L.) Osbeck Essential Oil against Multidrug-Resistant Pathogenic dermatophytes Isolated from Tinea capitis Samples

Article 7, Volume 5, Issue 2, December 2021, Page 275-287  XML PDF (267.98 K)
Document Type: Review Article
DOI: 10.21608/aps.2021.87917.1066
Authors
Hussain Y. Ungo-kore email orcid 1; Ehinmidu J. Olorunmola2; Onaolapo J. Ademola2; Olonitola O. Stephen3
1Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto 2346, Sokoto, Nigeria
2Department of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna 1044, Nigeria
3Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna 1044, Nigeria
Abstract
Many conventional antifungal agents are becoming ineffective against resistant strains of dermatophytes and as such the use of essential oil (EO) may confer a possible panacea to fight against such multidrug-resistant dermatophytes. This study is aimed at determining the antidermatophytic activity of EO from fruit peel of Nigerian Citrus senensis (L.) Osbeck against multidrug-resistant (MDR) tinea capitis dermatophytes and possible chemical composition. The EO was reaped by hydro-distillation and the chemical composition was investigated using gas chromatography/ mass spectroscopy (GC-MS).The antidermatophytic activity was evaluated using agar diffusion method against four dermatophyte strains (Two MDR dermatophytes, one referenced strain and one susceptible).The minimum inhibitory and fungicidal concentrations (MIC/MFC) were determined by agar dilution methods. The major components were terpenes: - D-Limonene (26.64 – 63.27%), α-terpineol (2.38 – 39.36%), β-linalool (2.28 – 13.42%), Carveol (1.36 – 3.91%), Carvone (3.62 – 3.80%) and α-Farnesene (1.29-1.83 %). Other non terpenes include 2,3,4,5-Tetrahydropyridazine (0.83%). The test results revealed EO to be active against all strains.The EO subjected to boiling temperature (100 0C) had increased amount of α-terpineol, β-Linalool, Carveol, Carvone and other imaginative compounds such as 1-Octanol (Heptyl carbinols) with increased antidermatophytic activity (inhibition diameters from 16.00 ± 0.00 - 22.67 ± 0.33 mm at a dilution of 1/16). To the best of our knowleged, this is the first description of the activity of Citrus senensis (L.) Osbeck fruit EO against multidrug-resistant tinea capitis dermatophytic strains. Our study suggests that this EO could be used clinically to treat or prevent dermatophytic infections with multidrug-resistant strains.
Keywords
Multidrug-resistant dermatophytes; Citrus senensis (L.) Osbeck; Essential oil; GC-MS; antidermatophytic activity
Statistics
Article View: 167
PDF Download: 125
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.