HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently, successful inhibitors target the polymerase function of HIV-RT. RNase H evolves to be a promising target for anti-HIV drug research. This review describes the compounds reported as HIV-1 RNase H inhibitors.
Mitry, M., Abdou, N., & Serya, R. (2018). HIV-1 RT-Associated RNase H review. Archives of Pharmaceutical Sciences Ain Shams University, 2(1), 22-30. doi: 10.21608/aps.2018.18731
MLA
Madonna M. A. Mitry; Nermin S. Abdou; Rabah A. T. Serya. "HIV-1 RT-Associated RNase H review", Archives of Pharmaceutical Sciences Ain Shams University, 2, 1, 2018, 22-30. doi: 10.21608/aps.2018.18731
HARVARD
Mitry, M., Abdou, N., Serya, R. (2018). 'HIV-1 RT-Associated RNase H review', Archives of Pharmaceutical Sciences Ain Shams University, 2(1), pp. 22-30. doi: 10.21608/aps.2018.18731
VANCOUVER
Mitry, M., Abdou, N., Serya, R. HIV-1 RT-Associated RNase H review. Archives of Pharmaceutical Sciences Ain Shams University, 2018; 2(1): 22-30. doi: 10.21608/aps.2018.18731
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