• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Archives of Pharmaceutical Sciences Ain Shams University
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 6 (2022)
Volume Volume 5 (2021)
Issue Issue 2
Issue Issue 1
Volume Volume 4 (2020)
Volume Volume 3 (2019)
Volume Volume 2 (2018)
Volume Volume 1 (2017)
Elsayed, N., Aboshanab, K., Yassien, M., Aboulwafa, M., Hassouna, N. (2021). Scaling up, Kinetic modeling, and Economic analysis of poly (3-hydroxybutyrate) production by Bacillus cereus isolate CCASU-P83. Archives of Pharmaceutical Sciences Ain Shams University, 5(1), 158-170. doi: 10.21608/aps.2021.76831.1061
Noha S. Elsayed; Khaled M. Aboshanab; Mahmoud A. Yassien; Mohammad M. Aboulwafa; Nadia A. Hassouna. "Scaling up, Kinetic modeling, and Economic analysis of poly (3-hydroxybutyrate) production by Bacillus cereus isolate CCASU-P83". Archives of Pharmaceutical Sciences Ain Shams University, 5, 1, 2021, 158-170. doi: 10.21608/aps.2021.76831.1061
Elsayed, N., Aboshanab, K., Yassien, M., Aboulwafa, M., Hassouna, N. (2021). 'Scaling up, Kinetic modeling, and Economic analysis of poly (3-hydroxybutyrate) production by Bacillus cereus isolate CCASU-P83', Archives of Pharmaceutical Sciences Ain Shams University, 5(1), pp. 158-170. doi: 10.21608/aps.2021.76831.1061
Elsayed, N., Aboshanab, K., Yassien, M., Aboulwafa, M., Hassouna, N. Scaling up, Kinetic modeling, and Economic analysis of poly (3-hydroxybutyrate) production by Bacillus cereus isolate CCASU-P83. Archives of Pharmaceutical Sciences Ain Shams University, 2021; 5(1): 158-170. doi: 10.21608/aps.2021.76831.1061

Scaling up, Kinetic modeling, and Economic analysis of poly (3-hydroxybutyrate) production by Bacillus cereus isolate CCASU-P83

Article 12, Volume 5, Issue 1, June 2021, Page 158-170  XML PDF (773.42 K)
Document Type: Original Article
DOI: 10.21608/aps.2021.76831.1061
Authors
Noha S. Elsayed email 1; Khaled M. Aboshanaborcid 1; Mahmoud A. Yassien1; Mohammad M. Aboulwafa2; Nadia A. Hassouna1
1Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
21. Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University 2. Faculty of Pharmacy, King Salman International University, Ras-Sedr, South Sinai, Egypt
Abstract
Background: Polyhydroxyalkanoates (PHA) are environmentally friendly polymers produced by many bacteria under nutrient-limited conditions. However, their commercialization is hindered by the production expenses. The present study aimed at cost-effective and efficient production of poly(3-hydroxybutyrate) (PHB) by Bacillus (B.) cereus isolate CCASU-P83.
Methods: Through one factor at time optimization study on shake flask, B. cereus CCASU-P83 produced about 50 % polymer per dry weight after 48 hours incubation time. For better evaluation of the fermentation process, kinetic modeling using the Logistic and Leudking-piret models was applied. Results: A preliminary economic analysis was carried out and leads to a 30.8 % reduction in the total cost. In comparison to the findings obtained on the level of shake flask, scaling up to the bioreactor resulted in producing about 53% PHB per dry weight after only 24 hours incubation. These models concluded that B. cereus produced PHB during the growth phase. Analysis of molecular weight of the produced polymer displayed a 26900 g/mole molecular weight with a polydispersity index (PDI) of 1.1.
Conclusion: B. cereus CCASU-P83 is a potential candidate for industrial production of PHB polymer using corn oil in a short incubation period which highly reduced the cost of the production process.
Keywords
Polyhydroxyalkanoates; Logistic; Leudking; Fermentation; optimization
Statistics
Article View: 206
PDF Download: 211
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.