Refaat, R., Eldeeb, A., Bakir, M., El-Abd, E., El-Bassiouni, E. (2020). Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat. Archives of Pharmaceutical Sciences Ain Shams University, 4(1), 104-112. doi: 10.21608/APS.2020.2004.1030
Rowaida Refaat; Asmaa Eldeeb; Marwa Bakir; Eman I El-Abd; Emad El-Bassiouni. "Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat". Archives of Pharmaceutical Sciences Ain Shams University, 4, 1, 2020, 104-112. doi: 10.21608/APS.2020.2004.1030
Refaat, R., Eldeeb, A., Bakir, M., El-Abd, E., El-Bassiouni, E. (2020). 'Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat', Archives of Pharmaceutical Sciences Ain Shams University, 4(1), pp. 104-112. doi: 10.21608/APS.2020.2004.1030
Refaat, R., Eldeeb, A., Bakir, M., El-Abd, E., El-Bassiouni, E. Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat. Archives of Pharmaceutical Sciences Ain Shams University, 2020; 4(1): 104-112. doi: 10.21608/APS.2020.2004.1030
Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat
3Radiation Sciences Department, Medical Research Institute, Alexandria University, Alexandria, Egypt
Abstract
Diabetic nephropathy (DN) is the most frequent cause of the end-stage renal disease (ESRD) in about 33% of diabetic patients. The present study aimed to explore the renoprotective effects of simvastatin (SV) and rosuvastatin (RSU) on the kidney of streptozotocin (STZ)-induced diabetic Sprague-Dawley (SD) rat model. As a result of induction of diabetes, serum [cystatin C, transforming growth factor-beta (TGF-β), and 8-hydroxy-2' -deoxyguanosine (8-OHdG)] and tissue [interleukin 1 beta (IL-1β), interleukin 10 (IL-10), prostaglandin E2 (PGE2), cytochrome c, malondialdehyde (MDA), glutathione (GSH), glutathione disulfide (GSSG), GSH/GSSG ratio) markers showed significant increase than negative controls except tissue total glutathione (tGSH). Both SV and RSU significantly shifted the levels back toward near non-diabetic values. Both exerted the same renoprotective effect indicated by a significant decrease in cystatin C. However, SV significantly lowered IL-10, GSH/GSSG ratio, MDA, and 8-OHdG than RSU. Similarly, RSU significantly lowered cytochrome c and GSSG than SV. In conclusion, SV and RSU have differential renoprotective effects via alteration of growth factor, inflammatory, oxidative stress, DNA damage, and apoptotic signaling pathways.
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