Phytochemical screening and antioxidant activity of Terminalia muelleri benth. leaf extract
Nouran
Fahmy
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, 11566, Egypt
author
Eman
Al-Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, 11566, Egypt.
author
Abdel Nasser
Singab
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, 11566, Egypt.
author
text
article
2017
eng
In the present investigation, leaves of Terminalia muelleri were assayed for their phytochemical constituents, as well as its free radical scavenging activity. The antioxidant effect was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging assay, the phytochemical constituents were screened to assess their corresponding effect on antioxidant activity. The results showed that the ethanol soluble fraction of T. muelleri possesses a potent radical-scavenging activity using the DPPH• (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging assay (IC50 value = 2.7 μg/mL, while the standard ascorbic acid has an IC50 value = 10.5 μg/mL).
Archives of Pharmaceutical Sciences Ain Shams University
Ain Shams University, Faculty of Pharmacy
2356-8380
1
v.
1
no.
2017
1
4
https://aps.journals.ekb.eg/article_10355_f7628a1c06989a2e4007156cf10dbade.pdf
dx.doi.org/10.21608/aps.2017.10355
HPLC Standardization of The Methanolic Extract of Acrocarpus fraxinifolius leaves based on Gallic acid Content
Heba
El-Nashar
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, Abassia, 11566, Egypt
author
Omayma
Eldahshan
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, Abassia, 11566, Egypt
author
Abdel Nasser
Singab
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, 11566, Egypt.
author
text
article
2017
eng
High-Performance Liquid Chromatography (HPLC) was developed for the standardization and quantification of gallic acid in the methanolic extract of Acrocarpus fraxinifolius Weight & Arn leaves. Linearity was observed in the range of 0.4–2 mg/mL with a correlation coefficient (r2) of 0.9978. The limit of detection (LOD) and limit of quantification (LOQ) were 0.0054 mg/mL and 0.0163 mg/mL, respectively indicating the sensitivity of the applied method. Recovery values of 100.377 % indicate the best accuracy of the method. Gallic acid content was quantified as 168.75 ± 1.05 mg/g methanolic extract. This developed method was simple, accurate and precise to be used as a reference standard method for determination of gallic acid content in the plant extract.
Archives of Pharmaceutical Sciences Ain Shams University
Ain Shams University, Faculty of Pharmacy
2356-8380
1
v.
1
no.
2017
5
8
https://aps.journals.ekb.eg/article_10356_fbe0b4ae8ba246491c62e00e193113c8.pdf
dx.doi.org/10.21608/aps.2017.10356
Hepatoprotective activity of aerial parts of Erythrina crista-galli
Nahla
Ayoub
Departments of Pharmacognosy, Faculty of Pharmacy,
Ain Shams University, Cairo, Egypt.
author
Ashraf
Abdel-Naim
Pharmacology and Toxicology, Faculty of Pharmacy,
Ain Shams University, Cairo, Egypt.
author
Mohamed
Ashour
Departments of Pharmacognosy Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
author
Naglaa
Mostafa
Departments of Pharmacognosy, Faculty of Pharmacy,
Ain Shams University, Cairo, Egypt.
author
text
article
2017
eng
Hepatoprotective activity was measured for Erythrina crista-galli extract as well as fractions. Fractions II and III have shown a remarkable protective effect against CCl4-induced hepatocyte injury. This was evidenced by their ability to significantly ameliorate CCl4-induced elevation in ALT and AST levels. This is supported by the notion that pretreatment of hepatocytes with either Erythrina crista-galli extracts or fractions significantly alleviated CCl4- induced GSH and SOD depletion and replenished CCL4 reduction of TAC. Hepatoprotective activity mechanism is attributed at least in part, to the free radical scavenging and antioxidant activity of the phenolic compounds present in the extract proved by the phytochemical screening of the fractions.
Archives of Pharmaceutical Sciences Ain Shams University
Ain Shams University, Faculty of Pharmacy
2356-8380
1
v.
1
no.
2017
9
15
https://aps.journals.ekb.eg/article_10357_bbcdfbc78183a56911052bf34a17b576.pdf
dx.doi.org/10.21608/aps.2017.10357
Genus Enterolobium : traditional uses, chemistry and biological activities
Mariam
Gamal El-Din
Department of Pharmacognosy; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
author
Omayma
Eldahshan
Department of Pharmacognosy; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
author
Abdel-Nasser
Singab
Department of Pharmacognosy; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
author
Nahla A.
Ayoub
Department of Pharmacognosy, Faculty of Pharmacy, British University in Egypt (BUE),Egypt
author
text
article
2017
eng
The chemical composition, pharmacological activity and traditional uses of 20 species attributed to the genus Enterolobium (Fabaceae) as used in the South and Central America, and Tropical Africa, were revised and compared. A survey of the available literature shows that these species are used mostly for their anti-inflammatory and cytotoxic activities. Additionally, some of these Enterolobium species showed antibacterial, antifungal, insecticidal, molluscicidal and larvicidal activities. Generally, the triterpenes or the phenolic compounds isolated from these plant extracts are assumed to be the bioactive principles.
Archives of Pharmaceutical Sciences Ain Shams University
Ain Shams University, Faculty of Pharmacy
2356-8380
1
v.
1
no.
2017
16
25
https://aps.journals.ekb.eg/article_10358_7b1d540771d01a34adcfd5e9d2404381.pdf
dx.doi.org/10.21608/aps.2017.10358